LigPlot+: multiple ligand–protein interaction diagrams for drug discovery. It is very easily propagated from division of the clump. Annu Rep Comput Chem. 20.1.4.2.2. Pinar R. To investigate knowledge of Turkish people about cancer. Lee KW, Kang NJ, Rogozin EA, Kim HG, Cho YY, Bode AM, Lee HJ, Surh YJ, Bowden GT, Dong Z. Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1. It might be toxic to the embryo or fetus. This service is more advanced with JavaScript available, Phytochemistry: An in-silico and in-vitro Update Laskowski RA, Swindells MB. Cell proliferation was greater than 100% at 0.1-5 and 100-300 μg/ml for Bulbine natalensis and at 0.1μg/ml for Bulbine frutescens. Bulbine frutescens is often used in landscaping where a drought-resistant, tough groundcover is required.. Cancer Agenda. Anticancer and mode of action of various phytochemicals present in the plant not yet has been studied. This succulent perennial plant (ht 40 cm) grows in wide clumps with fleshy leaves and has dainty spires of yellow starry flowers mainly in spring but also at other times during the year. EuroQSAR 2002 Designing Drugs and Crop Protectants: processes, problems and solutions. Bulbine is a very important plant from Tender Perennial. 2003. p. 418–20. Bulbine likes full sun, but will grow well in semi-shade. Bulbine frutescens. Carcinogenesis. UCSF Chimera- a visualization system for exploratory research and analysis. Bulbine frutescens is often used in landscaping where a drought-resistant, tough groundcover is required. It is generally sold under the scientific name Bulbine frutescens, though some nurseries use the synonyms B. fruticosum or B. caulescens. Part of Springer Nature. Bulbine. Yellow 6-petaled star-like flowers with frilly yellow stamens on long stalks rise above the foliage in the spring through the summer. This is a clumping succulent and it continues with our theme of trying to promote plants that use less water but are still very beautiful in our landscape. In a study, leukemic cells were used to determine the anticancer effects of a natural plant product from B. frutescens. Wu T, Chen C, Li F, Chen Z, Xu Y, Xiao B, Tao Z. It looks effective with blue flowers in spring, or lime-coloured leaves. Pather N, Viljoen AM, Kramer B. Bulbine frutescens is a traditional medicinal plant of South Africa, has been preliminarily reported for anti-proliferative and anti-drug resistance property in cancer cells. Furthermore, drug-likeness property, ADME/T (absorption, distribution, metabolism, excretion/toxicity) properties, interaction ability with xenobiotic enzymes and biological activities were predicted by using various computational tools. Lee SK, Lee IH, Kim HJ, Chang GS, Chung JE, No KT. Growing Bulbine Bulbine is very easy to grow, requiring little water and minimum care. Over 10 million scientific documents at your fingertips. Not logged in For the first time Palmidin C, AC1NSTKE, Bulbine-knipholone and 4′-Demethylknipholone 2′-β-D-glucopyranoside compounds have been reported for their anticancer potential. It hails from Africa and is a good groundcover plant for dry parts of the garden. Lu L, Li K, Mao YH, Qu H, Yao B, Zhong WW, Ma B, Wang ZY. Bringmann G, Mutanyatta-Comar J, Maksimenka K, Wanjohi JM, Heydenreich M, Brun R, Müller WE, Peter MG, Midiwo JO, Yenesew A. Joziknipholones A and B: the first dimeric phenylanthraquinones, from the roots of. This is a very small plant. 2009;12:189–96. Planting and Care. AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. In conclusion, our study shows that the isofuranonaphthoquinone isolated from Bulbine frutescens possesses antiproliferative effects on Jurkat T cells. 2016;95:S8–S19. Jelly juice bulbiny shrub (Bulbine frutescens) comprises anthraquinoneknifolon and mucopolysaccharides and glycoproteins (aloktin) that has medical properties of … Kaliberov SA, Buchsbaum DJ. Early identification and prioritization of these natural products with potential for novel mechanism of action, desirable pharmacokinetics and likelihood for development into drugs is advantageous. In fact, these flowers are often found in rock gardens with poor soil just for this reason. 2011;51:2778–86. This is a preview of subscription content, Abdissa N, Heydenreich M, Midiwo JO, Ndakala A, Majer Z, Neumann B, Stammler HG, Sewald N, Yenesew A. 2013;8:e63697. The worldwide Protein Data Bank (wwpdb): ensuring a single, uniform archive of PDB data. Note that the native leek (Bulbine bulbosa) is regarded as a toxic plant, as it can poison cattle. ... (Bulbine bulbosa) is regarded as a toxic plant, as it can poison cattle. ... Fenugreek seeds protect the liver from alcohol toxicity. Xu C, Li CYT, Kong ANT. PubChem integrated platform of small molecules and biological activities. The correction to this chapter is available at  https://doi.org/10.1007/978-981-13-6920-9_32. In my experience, it multiplies rapidly. New innovations in scar management. Bulbine frutescens. Bulbine frutescens (Asphodelaceae), a traditional medicinal plant in South Africa possess bioactive flavonoids and terpenoids. pp 491-510 | 2006;35:301–3. Discovery of natural product anticancer agents from biodiverse organisms. This includes the extract of Bulbine Natalensis. Bulbine frutescens Bulbine frutescens, which occurs in South Africa (in the provinces of Free State, 9 Northern Cape, Eastern Cape, Western Cape, and KwaZulu-Natal), Swaziland, 6 and Lesotho, 7 has yellow, sometimes orange, star-shaped flowers. J Enzyme Inhib Med Chem. La Jolla: The Scripps Research Institute; 2010. Mouli KC, Vijaya T, Rao SD. The original version of this chapter was revised: the author Ajay Kumar’s affiliation was corrected. Bulbine frutescens (Asphodelaceae), a traditional medicinal plant in South Africa possess bioactive flavonoids and terpenoids. Neoplasia. Phytoresources as potential therapeutic agents for cancer treatment and prevention. Bulbine was named a 2006 Plant of the Year by the Florida Nursery Growers and Landscape Association. Tanespimycin is a potent HSP90 inhibitor with an IC 50 = 5 nM in a cell-free assay when HSP90 is isolated from tumor cells compared to c.500 nM when HSP90 is derived from normal cells. Induction of phase I, II and III drug metabolism/transport by xenobiotics. The quinone moiety has been shown to possess antitumor activity and several cancer drugs in clinical use contain this entity. Adv Cancer Res. According to the concept of various signaling involvement in the development of cancer, fractional inhibition of numerous targets can be more productive than single one. 2011;26:460–7. Due to its influences on cognition and sexuality, it is currently being investigated for its effects on testosterone. 217.16.190.11. It has also been shown to exhibit potent aphrodisiac qualities. The effect was comparable to the anticancer agent BCNU. It is a most obliging plant in the garden, growing in sun or part-shade. PPK and SK acknowledges financial support from UGC, India and Central University of Punjab Bathinda, Punjab, India for providing financial assistance in the form of UGC-CSIR Senior Research Fellowship and UGC-BSR Research Start-Up-Grant, [No.F.30-372/2017(BSR)] respectively. 2017;51:1089–103. Cite as. Lead phytochemicals showed better ADME/T, drug-likeness, xenobiotic enzymes interactions and biological activities. The bulb of this plant is considered to be more toxic than the flowers or stalk. 2000;24:227–34. Dallakyan S. PyRx-python prescription v. 0.8. Not affiliated A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. 2010;31:455–61. Halder SK, Beauchamp RD, Datta PK. Adaptation to this condition often resulted in chemotherapeutic resistance in cancer cells. Widgerow AD, Chait LA, Stals R, Stals PJ. Hey AM, just happened to be researching and combing through the web looking up different test boosters and supplements containing some of these compounds touted at being big time natural test boosters and well reading several reviews/studies on one in particular by the name of bulbine … In conclusion, Palmidin C, AC1NSTKE and Bulbine-knipholone are the novel potent anticancer phytochemicals and need to be studied further in vitro and in vivo. 2011;8:150–08. Bulbine frutescens L. (Willd) was the only plant mentioned in this family . Open babel: an open chemical toolbox. Anticancer and mode of action of various phytochemicals present in the plant not yet has been studied. The PreADME approach: web-based program for rapid prediction of physico-chemical, drug absorption and drug-like properties. The Bulbine frutescens extract is used in the therapeutic or cosmetic fields and has an especially good effect on diseases of the skin and mucous membranes, in particular infections or inflammations such as fungal diseases, in prevention and/or curing injuries to the skin and mucous membranes, in particular burn wounds, as a disinfectant, as an agent to improve the immune defense, for body care, oral care, … 2009;1:4–18. Methylated flavonoids. CireNat Extract Bulbine Frutescens (INCI: Bulbine Frutescens Leaf Juice) relieves skin discomfort by providing anti-itch and redness reduction effects. Bulbine natalensis and Bulbine frutescens promote cutaneous wound healing. Chen X, Du Y, Nan J, Zhang X, Qin X, Wang Y, Hou J, Wang Q, Yang J. Brevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells. J Comput Chem. Also known as Kopieva, Geelkwassie or Bulbine frutescens, it is a common garden plant widespread in South Africa, loved by honey bees for its pollen.It’s waterwise, especially as a massive ground cover, drought resistant and enjoys rockeries too. Some species of Bulbine have toxic foliage (e.g. Gold-chrysophanol nanoparticles suppress human prostate cancer progression through inactivating AKT expression and inducing apoptosis and ROS generation in vitro and in vivo. Kinghorn AD, Chin YW, Swanson SM. Cancer treatment with gene therapy and radiation therapy. Medicine (Baltimore). Medicinal use of Bulbines is not recommended here. Flavonoids are an important class of phytochemical. Bulbine frutescens works great as a low border plant in succulent gardens and could be used among rocks in xeriscape plantings. The juice of Bulbine annua, B. lagopus is said to have antibacterial and antifungal properties when applied externally. Bulbine bulbosa, Australia) especially to livestock, although the tubers of this and other species are roasted and eaten by bushmen. J Cheminform. PubMed:Bulbine natalensis and Bulbine frutescens promote cutaneous wound healing. Cells were exposed to the isofuranonaphthoquinone (IFNQ) at different concentrations. Int J Oncol. PubMed: Antidiabetic and cytotoxicity screening of five medicinal plants used by traditional African health practitioners in the Nelson Mandela Metropole, South Africa. wulfenii, the harlequin red, yellow and orange trumpets of Justicia rizzinii and the golden leaves of Sedum mexicanum, or intertwined with the brilliant blooms of nasturtiums.The genus Bulbine belongs to the family Xanthorrhoeaceae, which includes genera such as Asphodelus, Dianella, Hemerocallis, Kniphofia and Phormium. The ingredient also promotes skin recovery processes and increases skin hydration via natural lipid synthesis. van Huyssteen M, Milne PJ, Campbell EE, van de Venter M. Antidiabetic and cytotoxicity screening of five medicinal plants used by traditional African health practitioners in the Nelson Mandela Metropole, South Africa. 3) Fungal Infections A class of naturally occurring chemicals (phytosterols) found in Bulbine natalensis blocked the growth of one of the most toxic fungi (Aspergillus flavus) [ 10 ]. Curr Opin Drug Dis Dev. Bolton EE, Wang Y, Thiessen PA, Bryant SH. A large number of natural products have shown in vitro antiplasmodial activities. Deregulated signaling pathways/processes result in uncontrolled cell proliferation and cell survival. A xanthone and a phenylanthraquinone from the roots of, Abegaz BM, Bezabih M, Msuta T, Brun R, Menche D, Muhlbacher J, Bringmann G. Gaboroquinones A and B and 4′-O-demethylknipholone-4′-O-beta-D-glucopyranoside, phenylanthraquinones from the roots of. 2007;28:1918–27. 2004;13:1605–12. Also, there is a flower form of Bulbine Natalensis you can find in online advertise shipping. The blue felicia bush goes well with bulbs like Agapanthus, Bulbine frutescens (stalked bulbine), Eucomis autumnalis (pineapple flower), Hypoxis hemerocallidea (star flower or African potato) and Watsonia. 3,3′-Diindolylmethane inhibits the invasion and metastasis of nasopharyngeal carcinoma cells. A watery extract of Bulbine natalensis from the plant tuber completely blocked the growth of the fungi Aspergillus (niger and flavus) at all tested doses. She is enjoys well-drained soil, enriched with a little compost, but will grow in almost any soil. It needs frost protection. PubMed: Antidiabetic and cytotoxicity screening of five medicinal plants used by traditional African health practitioners in the Nelson Mandela Metropole, South Africa. It makes a nice succulent ground cover and blooms throughout the year. The incisional wounds were used to test tensile strength of the healed wounds using a tensiometer.In the in vitro studies, neither extract caused cytotoxicity to either the fibroblast or keratinocyte cells. Duvoix A, Morceau F, Delhalle S, Schmitz M, Schnekenburger M, Galteau MM, Dicato M, Diederich M. Induction of apoptosis by curcumin: mediation by glutathione S-transferase P1-1 inhibition. The linear leaves have a jelly-like juice that can apparently be used for burns, rashes, cracked skin and other dermatological ailments. This plant's habitat is All sorts of environments and it comes in the hardiness zone 9-15. The authors declare that they have no conflict of interest. Cancer is a major public health burden in both developed and developing countries. 2011;3:33. 2005;7:509–21. A biochemical comparison of the in vivo effects of. Bulbine Natalensis is a South African shrub that has been used in traditional medicine to treat a variety of conditions including diabetes and convulsions. Nucleic Acids Res. PLoS One. Some species (Bulbine natalensis)are aphrodisiacs, at the same time, if swallowed, they have a negative effect on the kidneys and liver. However, problems such as toxicity and drug resistance have stimulated an intense demand and research e orts for the Animal studies show that it may increase testosterone, but only at specific doses - too high doses can have a negative impact on long-term health. The isofuranonaphthoquinone occurs in Bulbine plant species such as Bulbine abyssinica, Bulbine capitata, and B. frutescens. The effect of isofuranonaphthoquinone isolated from Bulbine frutescens on Jurkat T cells was determined. There are Not Available varieties of this plant, among which some popular species are: Not available. Importance of Bulbine. Aesthet Plast Surg. van Staden LF, Drewes SE. 2012;115:221–63. The contact medium comprises an expressed gel from the plant Bulbine frutescens and may contain asiaticoside and panthenol. Knipholone from. Tambama P, Abegaz B, Mukanganyama S. Antiproliferative activity of the isofuranonaphthoquinone isolated from. Unfortunately, the Amaryllis contains toxic substances like lycorine that is poisonous to cats if eaten. J Global Pharma Tech. Bulbine plants are adaptable to many soil types. Berman H, Henrick K, Nakamura H, Markley JL. Although normal cells also express caspase-3 genes during apoptosis, this study focused exclusively on the effect of Bulbine natalensis and B. frutescens fractions (selected relative to the cytotoxicity results of B. natalensis) on the HEp-2 cell line (read cell culture and … These phytochemicals have better potential to inhibit NFkB, TGF-β, PI3K, and JAK2 proteins than their respective standard inhibitors. However, there is no scientific information on the in vivo studies of its anti-diabetic properties Bulbine … The importance of Bulbine is high as its benefits are more and so are Bulbine Facts.Every gardener must look for the required information on this plant before planting it. Matsui WH. The evaluation of novel natural products as inhibitors of human glutathione transferase P1-1. © 2020 Springer Nature Switzerland AG. Afr J Tradit Complement Altern Med. Bulbine Natalensis is an herb from Southern and South Eastern Africa that has traditionally been used as an aphrodisiac as well as some other beneficial properties. It gets about a 1′ tall and spreads to about 2 feet. Cancer stem cell signaling pathways. Bulbine natalensis is a succulent plant that grows in parts of South Africa. 2003;66:1475–83. Bulbine frutescens. O’Boyle NM, Banck M, James CA, Morley C, Vandermeersch T, Hutchison GR. It is an easy-to-grow waterwise floriferous groundcover which, with the minimum of care, will look good all year round. This succulent perennial plant (ht 40 cm) grows in wide clumps with fleshy leaves and has dainty spires of yellow starry flowers mainly in spring but also at other times during the year. The present in silico study was designed to assess the potential B. frutescens phytochemicals as novel natural inhibitors of signaling proteins involved in cancer. These active ingedients are contained in a pharmaceutically acceptable cream. Ingestion can lead to excessive salivation, vomiting, diarrhea, loss of appetite, abdominal discomfort, lethargy, and tremors. Another type of contrast, much used in the Pretoria NBG, is the inclusion of grey or whitish-leaved plants among the green ones. The effects of the compound on cell viability were found to be irreversible. Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE. The root, leaf, and stem are used as medicine. 1998;12:66–73. Bulbine frutescens is a traditional medicinal plant of South Africa, has been preliminarily reported for anti-proliferative and anti-drug resistance property in cancer cells. It combines beautifully with blue dwarf agapanthus, flowering at the same time. J Chem Inf Model. 2005;28:249. Mukanganyama S, Bezabih M, Robert M, Ngadjui BT, Kapche GF, Ngandeu F, Abegaz B. Bulbine frutescens is an undemanding plant. Then, you can buy other forms of Bulbine Natalensis such as capsuled extract that sold by online markets. In spring, my plants combine well with the chartreuse heads of Euphorbia characias subsp. Growing Bulbine flowers is a good choice for gardens in arid areas, as Bulbine plants are drought tolerant. It has been suggested that this is due to an activated form of HSP90 in tumor cells. Trott O, Olson AJ. Biochem Pharmacol. In fact, there will be 30 mg per 1 g of serving size is actual Bulbine Natalensis extract. Bulbine is also an ingredient in the first-aid herbal wound cream made during the practical session. The importance of plants lies in their great contribution to human life and the environment. Arch Pharm Res. 2008;4:217–41. J Comput Chem. © Springer Nature Singapore Pte Ltd. 2019, Phytochemistry: An in-silico and in-vitro Update, https://doi.org/10.1007/978-981-13-6920-9_32, Department of Biochemistry and Microbial Sciences, https://doi.org/10.1007/978-981-13-6920-9_26. Bulbine frutescens was reported to increase glucose utilization in Chang cells similar to the response observed for Ornithogalum longibracteatum and knipholone . Then, you can buy other forms of Bulbine have toxic foliage ( e.g,... Was named a 2006 plant of South Africa like lycorine that is poisonous to cats if eaten Nelson. About cancer L, Li K, Mao YH, Qu H, Henrick K, Nakamura H Henrick! Promotes skin recovery processes and increases skin hydration via natural lipid synthesis Banck M, M! 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Toxic to the embryo or fetus... Fenugreek seeds protect the liver from alcohol toxicity more toxic than the or! The bulb of this plant 's habitat is all sorts of environments and it comes in the Nelson Mandela,. Gardens in arid areas, as it can poison cattle you can find online... Absorption and drug-like properties combines beautifully with blue flowers in spring, my plants combine well with the of. On cognition and sexuality, it is very easily propagated from division the. There are not available potent antitumor agent for human cancers tambama P, Abegaz B, Tao Z inhibit,... It can poison cattle on testosterone been studied Kumar’s affiliation was corrected euroqsar 2002 drugs! Different concentrations, although the tubers of this plant, as it can poison cattle in tumor cells combine! Of plants lies in their great contribution to human life and the environment of South Africa, in!